PENDUGAAN MODEL RANCANGAN CAMPURAN-CAMPURAN DENGAN PETAK TERBAGI
Abstract
Mixture-mixture design with a split plot was proposed for simultaneously two mixture systems. The complete model was formed by multiplying cubic models for two systems. The design was applied to the simultaneous optimizations of both mobile phase chromatographic mixtures and extraction mixture for the Phyllanthus niruri L. In this experiment used split plot approach. Saturated model coefficients were hypothesized with confident interval 99%. Reduction model consisted of real coefficients in complete coefficient models. Estimation method of reduction model coefficients consisted of Ordinary Least Square (OLS) and Generalized Least Square (GLS). Models were formed to count sum peaks chromatographic at 225, 254, and 260 nm. RMSEP values in OLS method at wavelength 225, 254, and 260 nm were produced 4.122, 3.049, and 2.56, otherwise RMSEP values in GLS method were 3.99, 2.79, and 3.18. There are component indicators in wavelength greater and more complex.
Key words : Mixture-mixture design, OLS, GLS, split plot
References
Borges C, Burns ER, Almeida AA, Scarminio IS . 2007. Mixture-mixture Design for the Fingerprint Optimization of Chromatograhic Mobile Phases and Extraction Solutions for Camellia sinensis. ScienceDirect 595:28-37.
Montgomery, D.C. 2002. A User Guide To Multivariate Calibration and Classification. Chichester, UK: NIR Publications.
Naes T, Isaksson T, Fearn T, Davies T . 2002. A User Guide To Multivariate Calibration and Classification. Chichester, UK: NIR Publications.
Naes T, Aastveit AH, Sahni NS. 2006. Analysis of split –plot design: an overview and comparison of methods. J Qual Reliab Engng Int 23:801-820.
Wahyuni, WT. 2010. Optimisasi dan Validasi Sidik Jari Kromatografi Cairan Kinerja Tinggi Ekstrak (Phyllanthus niruri L). [Tesis]. Bogor: Program Pascasarjana, Institut Pertanian Bogor
DOI: 10.33751/ekol.v12i1.254
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