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  2. Vol 11, No 1 (2021)
  3. Komalasari

REVIEW: KAJIAN SINTESIS MOLECULAR IMPRINTED POLYMER (MIP) UNTUK PENENTUAN ANABOLIK ANDROGENIK STEROID

Nensa Komalasari, Shendi Suryana, Dang Soni

Abstract


Molecular Imprinted Polymer (MIP) merupakan teknik pembuatan polimer berongga yang berfungsi sebagai sorben dengan selektivitas dan afinitas yang tinggi. Keberhasilan teknik MIP dalam pengaplikasiannya dilihat dari seberapa tingginya nilai imprinting factor (IF) dan kapasitas adsorpsi (KA) dalam mengadsorpsi suatu analit target. Tingginya kedua parameter tersebut dapat dipengaruhi oleh penggunaan monomer dan crosslinkers pada saat sintesis polimerisasi MIP. Tujuan dilakukan studi ini untuk memberikan informasi berupa nilai parameter IF dan KA dari penerapan MIP pada senyawa obat anabolik androgenik steroid (AAS). Review Jurnal ini dilakukan dengan menelusuri dan mengkaji jurnal ilmiah nasional maupun internasional tentang MIP dan AAS yang diperoleh dari situs google.com, google scholar, NCBI, dan Science Direct. Berdasarkan hasil review untuk memperoleh nilai IF dan KA yang tinggi bagi analit testosteron jika monomer yang digunakan adalah trifluoromethacrylic acid (TFMAA) yang dikombinasikan dengan crosslinker divinylbenzene (DVB) dan androsterone dimethacrylate (AnDMA), untuk analit estrogen seperti β-estradiol memperoleh nilai IF dan KA yang tinggi jika monomer yang digunakan adalah methacrylic acid (MAA) yang dikombinasikan dengan crosslinker ethylene glycol dimethacrylate (EGDMA).


Keywords


Molecular Imprinted Polymer; Anabolik Androgenik Steroid; Imprinting Factor; Kapasitas Adsorpsi.

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DOI: 10.33751/jf.v11i1.2594 Abstract views : 950 views : 652

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