Anti-inflammatory Potential of Mangosteen Pericarp Extract (Garcinia mangostana L.)

Auw Natasha Felicia Karnadi; Tjie Kok

doi:10.33751/jf.v13i1.7360

Anti-inflammatory Potential of Mangosteen Pericarp Extract (Garcinia mangostana L.)

Auw Natasha Felicia Karnadi, Tjie Kok

Abstract

Mangosteen pericarp (Garcinia mangostana L.) has been used as an active ingredient in numerous traditional medicine formulations. However, their function as an anti-inflammatory agent has yet to be fully understood. Macrophage migration inhibitory factor (MIF) is a mediator that is essential for the development of pro-inflammatory reactions. Hence, MIF activity is often associated with inflammatory diseases and its inhibition could therefore be used as an approach to assess the potential of a material as anti-inflammatory agent. In this study, MIF was exposed with mangosteen pericarp extracts in order to assess the possible anti-inflammatory effect of the extract. The type of mangosteen pericarp extract that possesses the greatest potential as MIF inhibitor and its IC₅₀ value were determined. Based on the results, n-hexane extract of mangosteen pericarp possesses the activity as MIF inhibitor with an IC₅₀ of 4.24 mg/L, and therefore could potentially be used as an anti-inflammatory agent.

Keywords

Garcinia mangostana (L); Pericarp extract; Anti-inflammation; MIF

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DOI: 10.33751/jf.v13i1.7360